TY - JOUR T1 - Oxidative stress and systemic inflammation in different COPD phenotypes JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 208 AU - Piero Ceriana AU - Giuseppe Brunetti AU - Teresa Coccini AU - Elisa Roda AU - Antonio Spanevello Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/208.abstract N2 - Introduction – Oxidative stress (OS) and systemic inflammation (SI) play a pivotal role in chronic obstructive pulmonary disease (COPD). It is not clear whether the degree of OS and SI may differ between the COPD phenotypes (P). Methods - We selected 36 COPD patients having clinical and radiological features of two distinct phenotypes. 18 patients belonging to the emphysema P (EP) had a history of COPD without cough or phlegm, were thinner, had low intensity sounds at auscultation, impaired lung diffusing capacity and definite emphysematous pattern at HRCT. 18 patients belonging to the bronchitis P (BP) had chronic productive cough, adventitious chest sounds at auscultation and radiological signs of increased bronchial and vascular markers. During a phase of clinical stability, the following markers of OS and SI were assessed in both groups and in a third group of 18 peer-age healthy people: F2 isoprostanes (F2-IP), superoxide dismutase 1 (SOD-1), monocyte chemotactic protein-1 (MCP-1), interleukin (IL) 8 and 6. Results – F2-IP was significantly higher (p<0.05) in both EP (191 pg/ml) and BP (209 pg/ml) compared to controls (96 pg/ml), MCP-1 was significantly higher in EP (290 pg/ml, p<0.01) and BP (267 pg/ml, p<0.05) compared to controls (204 pg/ml). SOD-1 was significantly lower (p<0.01) in EP (121 U/ml) compared to controls (165 U/ml)while no differences were observed for IL8 and IL6. Conclusions – some SI markers are higher in both COPD phenotypes while antioxidants are reduced, especially in the EP. ER -