RT Journal Article
SR Electronic
T1 Non-invasive measurement of respiratory impedance in unsedated healthy infants
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 186
VO 44
IS Suppl 58
A1 Diane Gray
A1 Dorottya Czövek
A1 Lauren Willemse
A1 Ane Alberts
A1 Zoltán Gingl
A1 Heather J. Zar
A1 Peter D. Sly
A1 Zoltán Hantos
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/186.abstract
AB Background: Assessing lung mechanics non-invasively in healthy infants offers the potential to better understand lung growth and function. The forced oscillation technique (FOT) requires minimal co-operation from the patient, but has rarely been used in infants.Aim: To assess the feasibility of a modified FOT to measure respiratory mechanics in unsedated infants.Method: Infants enrolled in a birth cohort study in South Africa had lung function measured at 6 to 10 weeks of age using FOT. Respiratory impedance (Zrs) was measured in the frequency range 8-48 Hz via a facemask during natural sleep. Respiratory system resistance (R), compliance (C) and inertance (I) were calculated from the Zrs data.Results: Of the 219 infants tested, 198 (90%) infants had successful measurements. The mean (SD) values of R, C and I were 52.2 (18.1) hPa.s.L-1, 0.83 (0.4) mL.hPa-1 and 0.071 (0.041) hPa.s2.L-1, respectively. Gender was a determinant for R and C, while C was significantly affected by maternal smoking during pregnancy.View this table:Resistance (R), Compliance (C) and Inertance (I) by gender and maternal smokingConclusion: The modified FOT technique is a feasible method for measuring respiratory mechanics in healthy unsedated infants. The FOT has the potential to be used as a tool in the assessment of determinates of early lung function.