RT Journal Article
SR Electronic
T1 The combination of elevated FeNO and blood eosinophils relate to reduced lung function and increased bronchial responsiveness in young asthmatics
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3409
VO 44
IS Suppl 58
A1 Andrei Malinovschi
A1 Lennart Nordvall
A1 Borres Magnus
A1 Janson Christer
A1 Kjell Alving
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/3409.abstract
AB We have recently reported in a population-based study the independent and additive information of the fraction of exhaled NO (FeNO) and blood eosinophil (B-Eos) count in relation to asthma, wheeze and asthma exacerbations. In the present study, we investigated FeNO and B-Eos in relation to lung function, bronchial responsiveness and asthma symptoms in an asthma cohort.FeNO, B-Eos, FEV1 and PD20 methacholine were measured in 410 subjects (10-34 years; 209 women) with asthma and ongoing treatment.Subjects with both elevated FeNO (>25 ppb) and B-Eos (>0.3x109/L) had lower FEV1% (p<0.001), more nighttime dyspnea (p=0.02) and lower PD20 (p<0.001) than subjects with normal FeNO and B-Eos, as well as lower PD20 than subjects with either high FeNO or high B-Eos (both p<0.001) (Table 1). These results were consistent after adjusting for gender, age, height, weight, IgE sensitization to aeroallergens, and current ICS dose.View this table:Table 1. Asthma characteristics in relation to FeNO and B-EosIn conclusion, additive information of two inflammatory biomarkers, exhaled nitric oxide and blood eosinophils, was found with regard to reduced lung function, increased bronchial responsiveness and nighttime dyspnea in young asthmatics. This suggests that these patients may be in need of biomarker-directed asthma treatment.