RT Journal Article
SR Electronic
T1 Smoking habit and volatile organic compounds in exhaled breath of healthy subjects
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1138
VO 44
IS Suppl 58
A1 Carolin Wagner -Struwing
A1 Mª Angeles Munoz-Lucas
A1 Javier Jareno-Esteban
A1 Concepcion Civera-Tejuca
A1 Jose Angel Maldonado-Sanz
A1 Luis Callol-Sanchez
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1138.abstract
AB INTRODUCTIONTobacco smoke exposure increases oxidative stress and is related to respiratory diseases. Volatile organic compounds - VOC- (aldehydes and organic acids) in exhaled breath might be biochemical markers of oxidative stress and smoking habit.AIMSTo determine if there exists an association between specific VOC and the smoking habit of healthy subjects.MATERIAL AND METHODSObservational case-control study in healthy volunteers, divided into three groups: smokers, ex -smokers and non-smokers (according to SEPAR criteria) with normal spirometry and no evidence of respiratory disease. Breath samples were collected via a BioVOC container after a residual functional capacity maneuver. We analized six VOC (hexanal, heptanal, octanal, nonanal, propionic acid and nonanoic acid). Biochemical analysis was performed by TD/GC/MS (Markes-Agilent Tech). We used the SPSS® v-15 for Windows for statistical analysis.RESULTSWe included 89 healthy subjects with a mean age of 49.3 years. 42 male, 47 female. 30 were smokers, 24 ex-smokers and 35 non-smokers. The pack-year index was 30.9 (18.6) in smokers and 26.5 (21.6) in ex-smokers.Only nonanal showed statistical differences between the three groups (p 0.04). After dividing into tobacco-exposure (smokers and ex-smokers) and non tobacco exposure group, we also observed a statistical difference (p 0.019).There were no differences after stratification analysis for age and gender (male r 0.05, p 0.753, female r 0.081, p 0.588), andbetween the nonanal concentration and the amount of tobacco smoked.CONCLUSIONSNonanal could be a marker of oxidative stress in smokers and ex – smokers.We observed no association with age, gender or amount of tobacco consumption.