RT Journal Article SR Electronic T1 Geographic origin and other determinants of site of tuberculosis disease in European countries JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1695 VO 44 IS Suppl 58 A1 Nicolas Lefebvre A1 Dennis Falzon A1 Vahur Hollo A1 Marieke van der Werf A1 Andreas Sandgren A1 Giovanni Sotgiu YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/1695.abstract AB Background: The site of disease in tuberculosis (TB) influences transmissibility, diagnosis and treatment outcome. We explored host-related risk factors for site of TB disease using variables routinely collected for national surveillance by the European Centre for Disease Prevention and Control (ECDC).Methods: Logistic and multinomial regression models were fitted to non-nominal case-based data to identify determinants of site of disease from among age, sex, previous TB diagnosis, country of report and geographic area of origin.Results: Between 2003 and 2012, 24 European Union / European Economic Area countries reported a total of 406,673 TB cases with exclusive pulmonary (PTB; 82%) or extrapulmonary (EPTB; 18%) TB disease, and who had full data on all 5 explanatory variables. EPTB was associated with age <15 years (adjusted OR (aOR): 5.1; 95% CI 4.9-5.3), females (aOR: 1.7; 95% CI: 1.6-1.7), no previous TB (aOR: 2.9; 95% CI: 2.9-3.0), and geographic origin (aOR range: 0.6-3.8; reference: central Europe). Origin from the Indian subcontinent was most strongly associated with lymphatic (aOR: 24.1; 95% CI: 22.3-26.0), peritoneal/digestive (aOR: 16.6; 95% CI: 13.7-20.2) and disseminated (aOR: 38.1; 95% CI: 27.1-53.5) forms of disease; African origin was also strongly related to disseminated forms (aOR: 32.1; 95% CI: 25.3-40.7).Conclusions: Awareness of host-related determinants of site of TB is pertinent to diagnostics. The predilection for extra-pulmonary TB localisation among patients originating from outside Europe may reflect ethnic differences in disease manifestations and higher HIV prevalence.