PT - JOURNAL ARTICLE AU - Matthew Evison AU - Philip Crosbie AU - Julie Martin AU - Philip Barber AU - Richard Booton AU - Katie Hilton TI - Can computed tomography characteristics predict outcomes in patients undergoing radial EBUS-guided biopsy of peripheral lung lesions? DP - 2014 Sep 01 TA - European Respiratory Journal PG - P678 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P678.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P678.full SO - Eur Respir J2014 Sep 01; 44 AB - Introduction: Percutaneous CT-guided lung biopsy is the gold standard minimally invasive technique for sampling lung lesions beyond the reach of standard bronchoscopy. Radial EBUS offers an alternative approach but which patients are most suited to this procedure has not been defined. The primary aim of this study was to investigate whether CT characteristics could predict the success of radial EBUS.Methods: The University Hospital of South Manchester provides radial EBUS for a large cancer Network in the UK. Procedures are performed under conscious sedation without fluoroscopy, double-hinged curettes or guide sheaths. This retrospective analysis of a prospectively maintained database included all patients undergoing radial EBUS from January 2011 to June 2013. Lesion size, location, position, presence of a bronchus sign and morphology on CT were analysed against pre-defined outcomes using univariate and multivariate analysis.Results: 117 patients underwent radial EBUS in the study period (mean age 69.5, mean lesion size 36.6mm). 83% of lesions were ultimately proven to be malignant. The presence of a bronchus sign on CT was the only independent predictor of all three pre-defined outcomes: (i) lesion identification with radial EBUS, (ii) central probe position within the lesion and (iii) accurate diagnosis; OR 31.1 (7.8-123.9, p=0.0001), OR 44.8(5.6-354.9, p=0.0001) and OR 46.6 (11.1-195.3, p=0.0001) respectively.Discussion: The patients most likely to benefit from radial EBUS without adjuncts (fluoroscopy, curettes, guide sheaths) are those with a bronchus sign on CT, regardless of lesion size, lobar location, lesion position and morphology.