TY - JOUR T1 - The relationship between 24-hour symptoms and COPD exacerbations: Results from ASSESS JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P531 AU - Marc Miravitlles AU - Heinrich Worth AU - Juan José Soler Cataluña AU - David Price AU - Fernando De Benedetto AU - Nicolas Roche AU - Nina Skavlan Godtfredsen AU - Thys van der Molen AU - Claes-Göran Löfdahl AU - Laura Padullés AU - Anna Ribera Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P531.abstract N2 - BackgroundCOPD patients with repeated exacerbations tend to have more symptoms than patients without. The relationship between symptoms in different parts of the 24-hour day and exacerbations has not been evaluated.AimTo assess the relationship between COPD symptoms in each part of the day and exacerbations.MethodsIn this observational study, night-time, early morning and day-time COPD symptoms in the previous week (symptom questionnaire) and exacerbations in the previous year were assessed at baseline. Patients were followed for 6 months and exacerbations recorded. The relationship between 24-hour symptoms and exacerbations in both periods was assessed.Results727 patients were eligible (66% male, [mean±SD] age 67±9 years, % predicted post-bronchodilator FEV1 53±21%). The mean±SD number of exacerbations was 1.2±1.6 in the year prior to baseline and 0.7±1.5 during follow-up.Exacerbations in the previous year were associated with symptoms in each part of the 24-hour day; exacerbations during follow-up were associated with morning and day-time symptoms (Table). Exacerbations, pre-baseline and during follow-up, were more frequent in patients with night-time, early morning or day-time symptoms than patients with no symptoms in each period (Table).ConclusionAround the clock COPD symptoms were associated with more exacerbations. Most patients, irrespective of exacerbation history, had night-time and morning symptoms. ER -