PT  - JOURNAL ARTICLE
AU  - Rachel Roberts
AU  - Keir Lewis
TI  - Does smoking status at time of diagnosis of lung cancer independently predict survival at 6 months?
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P504
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P504.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P504.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Studies suggest that continued smoking after a diagnosis of Lung Cancer (LC) independently worsens quality of life, and shortens life expectancy, but these were retrospective and smoking was not validated biochemically1,2. We wanted to see if current smoking status independently affects prognosis in newly diagnosed LC.We report early findings from 406 patients with newly diagnosed LC who were followed for at least 6 months. Smoking status was verified by exhaled carbon monoxide (eCO) on every clinical visit.Smoking status was entered alongside performance status and T&M stage as into a multiple regression model with days survived since diagnosis as the dependent variable.73.6% of those who were smoking at the time of diagnosis were alive at 6 months, compared to 81.3% of ex- or never smokers (X2(1, N = 370) = 2.95, p =.57).View this table:Table to show the results of the stepwise multiple linear regression51% of patients who smoked experienced treatment complications compared to only 41% of patients who did not smoke, (p=.143).Smoking status appears an independent predictor of survival in NSCLC, alongside traditional factors. Quitting smoking could improve mortality. More recruits and data collection regarding histology, treatments and outcomes is ongoing but these results suggest smoking cessation treatments should be offered within LC MDTs and at all follow-up appointments.1. British Medical Journal; BMJ 2010:340:b5569.2. Chest. 2004; 126: 1733-41.