TY - JOUR T1 - The influence of complex ICS/LABA therapy on oxygen consumption in COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 3400 AU - Yuriy Feshchenko AU - Liudmyla Iashyna AU - Svitlana Opimakh Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/3400.abstract N2 - Background: Hypoxemia is one of the unfavorable consequences of chronic obstructive pulmonary disease (COPD). Combine therapy with inhaled corticosteroids (ICS) and long-acting beta2-agonists (LABA) improves lung function and health status in COPD patients. As such treatment has impact on oxygen consumption?Objectives: This study aimed to investigate the influence of complex ICS/LABA therapy on oxygen consumption in COPD patients.Methods: This was an observation of 10 patients (average age (63.6±4.1) years) with stable COPD, mean FEV1 (37.2±3.5)% of predicted, to whom complex ICS/LABA therapy (fluticasone propionate 1000 mcg daily, salmeterol 100 mcg daily) was prescribed. Oxygen content in the exhaled air was evaluated before and after 3 months therapy, specifically end-tidal O2 fraction (FETO2) and expired O2 fraction (FEO2). Data are presented as mean±SD.Results: We observed statistically significant improvement in oxygen exchange of the patients: reduced of FETO2 from (16.3±0.6) to (15.8±0.7) %, FEO2 from (17.8±0.5) to (17.4±0.5) % after the end of the 3 month therapy, for both p<0.05. We assume that in average COPD patient inhales atmospheric air with the O2 concentration 20.85 % and exhales air with an average O2 concentration 17.8 %, that metabolized 3.05 % oxygen before treatment. After the therapy oxygen consumption became 3.45 % that 13 % more than at baseline.Conclusion: The possible way of positive health changes under combine ICS/LABA therapy in COPD patients may be the improvement of oxygen delivery and consumption.The place of oxygen content in the exhaled air analysis on oxygen consumption control may be the subject of future research. ER -