RT Journal Article
SR Electronic
T1 Differences in pulmonary rehabilitation outcomes in patients after single or double lung transplantation
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P618
VO 44
IS Suppl 58
A1 Tessa Schneeberger
A1 Rainer Gloeckl
A1 Bernd Sczepanski
A1 Sandra Winterkamp
A1 Klaus Kenn
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P618.abstract
AB Introduction:PR following LTx can almost be seen as an established therapeutic modality. However, differences concerning the efficiency of pulmonary rehabilitation (PR) in patients with single (SLTx) or double (DLTx) lung transplantation have barely been studied yet.Methods:In a retrospective analysis (period: 1997-2013) 550 patients with COPD or interstitial lung diseases after LTx (SLTx: n=212, FEV1 55±18% pred., age: 58±6 ys; DLTx: n=338, FEV1 70±19% pred., age: 53±8 ys) were included. All patients underwent a standardized inpatient PR program of 41±18 days in average. Data of 6-minute walking distance (6MWD), health related quality of life (physical [PCS] and mental [MCS] component summary of the SF 36 questionnaire) and adverse events during PR have been registered and analyzed.Results:In SLTx patients, 6MWD increased from 267±134 to 381±120 (p<0,001), PCS from 32±9 to 39±10 and MCS from 40±17 to 48±15 (p<0,001 each). In DLTx patients, 6MWD increased from 284±144 to 412±126, PCS from 27±11 to 35±10 and MCS from 41±16 to 50±14 (p<0,001 each). DLTx patients improved their 6MWD significantly (p=0,045) more than SLTx patients. Benefits in HRQL were comparable in patients with SLTx and DLTx (p=n.s.). Frequency of adverse events was similar in both groups (bacterial infection [SLTx 16.5% vs. DLTx 20.4%]; virus infection (cytomegaly) [SLTx 13.2% vs. DLTx 9.2%]; all p=n.s.).Conclusion:These results show that patients benefit significantly and clinically relevant from a comprehensive PR program performed immediately after surgery to a similar extend with regard to HRQL. However exercise capacity improved significantly more in patients after DLTx.