RT Journal Article
SR Electronic
T1 Lung cancer screening in COPD patients: NLST criteria vs a COPD screening score
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P976
VO 44
IS Suppl 58
A1 Juan de Torres
A1 David Wilson
A1 Pablo Sanchez
A1 Joel Weissfeld
A1 Ana Belen Alcaide
A1 Arantza Campo
A1 Usua Montes
A1 Javier Zulueta
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P976.abstract
AB Objective: To explore NLST criteria among COPD patients and to develop a COPD-tailored score that improves it's predictive capability for LC risk.Methods: We analyzed the databases from the Pamplona-IELCAP LC screening study (P-IELCAP) and the Pittsburgh Lung Screening Study (PLuSS). Only patients with spirometricaly proven COPD were included. NLST criteria were applied to both populations. By logistic regression we determined which factors were independently associated with LC, and then developed a COPD screening score (COPDss).Results:Forty-eight percent of COPD patients in P-IELCAP and 30% in PluSS did not meet NLST criteria (Table 1, panel A), resulting in the exclusion of 33% and 22% of lung cancers in each cohort, respectively (panel B). Factors associated with lung cancer risk are shown in Table 2. Variables finally included in the calculation of the COPDss are shown in Table 3. Figure 1 shows the ROC for NLST criteria and for COPDss in each COPD cohort (panels 2 & 3), and in both combined (panel 1).Conclusions: In patients with COPD undergoing screening, NLST criteria results in the exclusion of a large proportion of patients with LC. The COPDss improves the prediction of lung cancer risk among COPD patients.