PT  - JOURNAL ARTICLE
AU  - Juan de Torres
AU  - David Wilson
AU  - Pablo Sanchez
AU  - Joel Weissfeld
AU  - Ana Belen Alcaide
AU  - Arantza Campo
AU  - Usua Montes
AU  - Javier Zulueta
TI  - Lung cancer screening in COPD patients: NLST criteria vs a COPD screening score
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P976
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P976.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P976.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objective: To explore NLST criteria among COPD patients and to develop a COPD-tailored score that improves it's predictive capability for LC risk.Methods: We analyzed the databases from the Pamplona-IELCAP LC screening study (P-IELCAP) and the Pittsburgh Lung Screening Study (PLuSS). Only patients with spirometricaly proven COPD were included. NLST criteria were applied to both populations. By logistic regression we determined which factors were independently associated with LC, and then developed a COPD screening score (COPDss).Results:Forty-eight percent of COPD patients in P-IELCAP and 30% in PluSS did not meet NLST criteria (Table 1, panel A), resulting in the exclusion of 33% and 22% of lung cancers in each cohort, respectively (panel B). Factors associated with lung cancer risk are shown in Table 2. Variables finally included in the calculation of the COPDss are shown in Table 3. Figure 1 shows the ROC for NLST criteria and for COPDss in each COPD cohort (panels 2 & 3), and in both combined (panel 1).Conclusions: In patients with COPD undergoing screening, NLST criteria results in the exclusion of a large proportion of patients with LC. The COPDss improves the prediction of lung cancer risk among COPD patients.