RT Journal Article
SR Electronic
T1 Does CTLA-4 and CD-28 polymorphism affect the lung involvement in Turkish ankylosing spondylitis patients??
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4505
VO 44
IS Suppl 58
A1 Fatmanur Karakose
A1 Aylin Rezvani
A1 Saime Turan
A1 Omer Uysal
A1 Muhammet Emin Akkoyunlu
A1 Nazli Ezgi Ozkan
A1 Mehmet Bayram
A1 Hatice Sozgen
A1 Fatih Yakar
A1 Hatice Ozcelik
A1 Murat Sezer
A1 Mustafa Guler
A1 Ilhan Yaylim
A1 Levent Kart
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P4505.abstract
AB Ankylosing spondylitis is a multisystemic disorder with ocular, pulmonary, and cardiovascular involvement. Data from AS patients who have amyloidosis, psoriasis suggest that immunologic or inflammatory mechanisms may be responsible for pathogenesis.Incidence of pulmonary involvement is 1 to 70%,but pathophysiology is still unknown.We aimed to address the relationship between CTLA4 and CD28 polymorphism in AS patients who have lung involvement.Enrolled were 80 controls and 89 AS patients diagnosed according to the Modified New York Criteria in the Physical Medicine and Rehabilitation Department of the Rheumatology Outpatient Clinic.CTLA4 and CD28 polymorphism analysis and clinical,radiological assessment were performed.We found a correlation between HRCT findings and CD 28 gene polymorphism,but no significant association was detected between CTLA4-318,CTLA4-49 and CD28 genotypes and the clinical characteristics of the patients. All patients with the CD28 CC genotype had abnormal HRCT to a statistically significant degree(p=0.047)but no other correlation was found between CTLA 4, CD28 gene polymorphism, and PFTs and clinical characteristics.