TY - JOUR T1 - Parental self-perceived body shape and offspring asthma JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4764 AU - Randi J. Bertelsen AU - Cecilie Svanes AU - Marie Waatevik AU - Bryndís Benediktsdóttir AU - Lennart Bråback AU - Shyamali Dharmage AU - Bertil Forsberg AU - Thorarinn Gislason AU - Christer Janson AU - Ane Johannessen AU - Mattias Holm AU - Rain Jogi AU - Eva Lindberg AU - Ferenc Macsali AU - Dan Norbäck AU - Ernst Omenaas AU - Eirunn Waatevik Saure AU - Vivi Schlunssen AU - Trude Duelien Skorge AU - Hilde Kristin Vindenes AU - Francisco Gomez Real AU - Julia Dratva Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4764.abstract N2 - Background: Body composition, in particular obesity, has been associated with asthma. Less is known about parents' body composition and asthma development in the child. We aimed to describe the association between parental self-perceived body shape at age 30 with asthma in the offspring.Method: In the Respiratory Health in Northern Europe (RHINE III) study conducted in 2012, the 35-67 year old index persons responded to a question that included nine body shapes varying from thin to obese, and chose the body shape resembling themselves at age 30. We used a multi-level random-effects regression model to estimate the odds for asthma in the offspring during the 10 first years of life by the parents' self-perceived body shape at age 30. The model included 9,445 index persons and 21,810 offspring (0-51 years old). The analyses were stratified by parental gender and adjusted for parental history of asthma, educational level, smoking, and frequency of physical exercise, age of children and parents (at data collection), study center, and family clustering.Results: Compared to a normal body shape, the odds for asthma in the offspring was increased if the mothers had a thin [OR=1.62 (95% CI: 1.01, 2.60)] or overweight/obese body shapes [OR= 1.80 (95% CI: 1.18, 2.74)] at age 30. The odds ratio for asthma in the offspring was 1.52 (95% CI: 0.97, 2.38) if the fathers reported overweight/obese body shapes at age 30.Conclusion: Both thin and obese self-perceived body shapes representing the parents' reproductive age (30 years) were associated with early childhood asthma in the offspring. This could point to some underlying metabolic condition in the parents that may influence disease development in the offspring. ER -