RT Journal Article
SR Electronic
T1 The roles of Ki-67, p53, transforming growth factor- and lysyl oxidase in the metastasis of lung cancer
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P345
VO 44
IS Suppl 58
A1 Omer Araz
A1 Elif Demirci
A1 Elif Yilmazel Ucar
A1 Muhammet Calik
A1 Adem Karaman
A1 Irmak Durur Subasi
A1 Ebru Orsal
A1 Mahmut Subasi
A1 Ferah Daloglu
A1 Metin Akgun
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P345.abstract
AB Objectives:This study aimed to evaluate the microscopic predictive molecular markers that play roles in metastasis. The secondary aim of the study was the investigation of the relationship between these parameters and the SUVmax of the primary lesion, obtained by PET-CT.Methods:Eighty-five patients with newly diagnosed LC were enrolled in this study. All patients were examined using the PET-CT and brain magnetic resonance imaging. Ki-67, p53, transforming growth factor-β (TGF-β), and lysyl oxidase (LOX) were evaluated histopathologically in all of the cases.Results:Immunohistochemical evaluations revealed small cell lung carcinoma (SCLC) as showing the most intense staining in all parameters and differentiated adenocarcinoma demonstrated a more diffuse and intense staining than squamous cell carcinoma (SCC). There was a statistically significant relationship between the parameters of TGF-β, LOX, and the metastasis of adenocarcinoma in terms of diffusivity and intensity; however, p53 and Ki-67 did not show a statistically significant relationship. These four parameters obtained from both the SCLC and SCC cases demonstrated no correlation to the SUVmax. In the case of adenocarcinoma, the diffusivity and intensity of the LOX and p53 staining showed a statistically significant relationship to the SUVmax; but for the other parameters, a statistically significant relationship was not seen.Conclusion:LOX and TGF-β may play roles in cases of metastases in lung adenocarcinoma. The inhibition of these factors and their signaling pathways can be used as a method of treatment for lung cancer.