RT Journal Article SR Electronic T1 Dynamic changes of Th1-cell immune response to ESAT-6 and CFP-10 during anti-tuberculosis treatment JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3063 VO 44 IS Suppl 58 A1 Lifan Zhang A1 Qiang Li A1 Yueqiu Zhang A1 Yanhua Song A1 Mengqiu Gao A1 Xiaochun Shi A1 Yanbin Zhang A1 Yao Zhang A1 Ajit Lalvani A1 Xiaoqing Liu YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P3063.abstract AB Introduction:To explore the dynamic changes of MTB specific Th1 immune response among Chinese patients receiving anti-TB therapy.Methods:Untreated TB patients were enrolled. At baseline and during treatment, the Fluorospot assay based on ESAT-6 and CFP-10 was performed to measure IFN-γ and/or IL-2 secreting T cells.Results:Of the fourteen untreated patients with ATB, 6 were microbiologically diagnosed. All 14 patients responded successfully to anti-TB therapy. Cellular reponses to ESAT-6-and CFP-10 showed identical patterns. Antigen-specific IFN-γ-only-secreting T cell were decreased in 12 patients after treatment, and the frequencies changed significantlyView this table:Frequencies of cytokine secreting T cells in TB patients during treatment. The proportions of antigen-specific IFN-γ-only-secreting T cell were significantly decreased during treatment in all but 4 patients, while the proportions of dual IFN-γ/IL-2-secreting T cell showed a reverse dynamic pattern.Conclusion:The Th1-cell response patterns changed significantly during treatment, while the association with clinical status need be further evaluated.