PT  - JOURNAL ARTICLE
AU  - Lifan Zhang
AU  - Qiang Li
AU  - Yueqiu Zhang
AU  - Yanhua Song
AU  - Mengqiu Gao
AU  - Xiaochun Shi
AU  - Yanbin Zhang
AU  - Yao Zhang
AU  - Ajit Lalvani
AU  - Xiaoqing Liu
TI  - Dynamic changes of Th1-cell immune response to ESAT-6 and CFP-10 during anti-tuberculosis treatment
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3063
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3063.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3063.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Introduction:To explore the dynamic changes of MTB specific Th1 immune response among Chinese patients receiving anti-TB therapy.Methods:Untreated TB patients were enrolled. At baseline and during treatment, the Fluorospot assay based on ESAT-6 and CFP-10 was performed to measure IFN-γ and/or IL-2 secreting T cells.Results:Of the fourteen untreated patients with ATB, 6 were microbiologically diagnosed. All 14 patients responded successfully to anti-TB therapy. Cellular reponses to ESAT-6-and CFP-10 showed identical patterns. Antigen-specific IFN-γ-only-secreting T cell were decreased in 12 patients after treatment, and the frequencies changed significantlyView this table:Frequencies of cytokine secreting T cells in TB patients during treatment. The proportions of antigen-specific IFN-γ-only-secreting T cell were significantly decreased during treatment in all but 4 patients, while the proportions of dual IFN-γ/IL-2-secreting T cell showed a reverse dynamic pattern.Conclusion:The Th1-cell response patterns changed significantly during treatment, while the association with clinical status need be further evaluated.