PT  - JOURNAL ARTICLE
AU  - Kazumasa Ogawa
AU  - Atsushi Miyamoto
AU  - Yui Takahashi
AU  - Makiko Takeyasu
AU  - Sayaka Mochizuki
AU  - Shigeo Hanada
AU  - Hironori Uruga
AU  - Hisashi Takaya
AU  - Nasa Morokawa
AU  - Atsuko Kurosaki
AU  - Hideki Araoka
AU  - Akiko Yoneyama
AU  - Kazuma Kishi
TI  - Clinicoradiological features of pulmonary tuberculosis associated with interstitial pneumonia
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2649
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2649.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2649.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - <Introduction> Pulmonary tuberculosis (TB) occasionally develops in patients with interstitial pneumonia (IP); however, there are few reported cases of TB with IP. The aim of this study was to evaluate the clinicoradiological features of TB patients who had IP. <Methods> Of 238 patients who showed positive results for Mycobacterium tuberculosis in sputum or bronchoalveolar lavage fluid cultures at the Toranomon Hospital, Japan from April 2007 to March 2013, we included 14 TB patients with IP (12 men, 2 women; median age, 73 years). We reviewed medical charts, high-resolution computed tomography (HRCT) findings, and bacteriological results. All HRCT findings were reviewed by a thoracic radiologist and two pulmonologists.<Results> Of these 14 patients, 8 had idiopathic IP and 4 received steroid therapy. The HRCT findings of TB were classified into 3 subtypes: typical, having centrilobular nodules or cavities (4 patients, 28.6%); atypical, showing consolidation adjacent to fibrotic or emphysematous lesions without nodules (8 patients, 57.1%); and unidentifiable, characterized by no apparent TB lesions owing to diffuse parenchymal infiltrate caused by acute IP exacerbations (2 patients, 14.3%). 8 patients were treated with isoniazid, rifampicin, and ethambutol, and 6, with isoniazid, rifampicin, ethambutol, and pyrazinamide; subsequently, 13 showed a negative sputum culture. Although 4 patients could not complete the TB treatment owing to worsening of their general status, no patient died.<Conclusion> It is often difficult to diagnose TB in patients with IP because of their atypical HRCT findings ; however, appropriate TB treatment leads to a favorable outcome.