RT Journal Article SR Electronic T1 Does CPAP treatment lead to gastroesophageal reflux in moderate and severe OSA cases? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2209 VO 44 IS Suppl 58 A1 Hatice Kutbay Özçelik A1 Ahmet Danalioglu A1 Mehmet Bayram A1 Muhammed Emin Akkoyunlu A1 Fatih Yakar A1 Fatmanur Karaköse A1 Murat Sezer YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2209.abstract AB Aim: To evaluate the CPAP treatments effect on formation of gastroesophageal reflux(GER) in the moderate and severe OSA cases. Methods: Thirty nine patients diagnosed OSA (moderate and severe) in our sleep laboratory and no history of GER prospectively enrolled to study. Twenty six of them were given esophageal manometer and pH meter for 24 hours, and 13 patients were excluded since intolerance for manometer. We repated esophageal manometer and pHmeter after one-month CPAP treatment to remained 13 patients. Results:Five of the patients were female and 21 were male. Median age was 48.4. Median Epworth score was 11, body mass index was 32, RDI was 40. Esophageal manometer before CPAP treatment showed that median lower esophageal sphincter pressure was 20, lower esofageal sphincter relaxation was 67%, and after a 24-hour pHmeter DeMeester score was 18. Pre-treatment sphincter relaxation insufficiency and age were correlated. After CPAP treatment avarage sphincter pressure was 21, sphincter relaxation was 51,and DeMeester score was measured 10,4. Before and after the CPAP treatment, no significant difference was observed among DeMeester score, sphincter pressure , and sphincter relaxation rates. However when evaluated individually, 7 patients show rising with their DeMeester score. Conclusion: Eventhough our study supports that the CPAP treatment may cause GER, there is necessity to do more research with more patients.