TY - JOUR T1 - Clinical evaluation of IP-10 and MIG including IGRAs (QFT and T-SPOT) for the diagnosis of tuberculosis infection JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2604 AU - Yoshihiro Kobashi AU - Masaki Ikeda AU - Keiji Mouri AU - Shigeki Kato AU - Mikio Oka Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2604.abstract N2 - [Objective] We focused on some chemokines related to IFN-gamma (IP-10 and MIG), and compared their usefulness for the diagnosis of TB infectionwith previous IGRAs (QFT and T-SPOT).[Materials and Methods] The subjects consisted of 33 cases with TB diseases (definite cases), 40 cases with pulmonary nontuberculous mycobacterial (NTM) disease, and 11 cases with other respiratory diseases. We measured two IGRAs and IP-10 and MIG using the supernatant stimulated by QFT antigens in all cases, and compared the usefulness of IGRAs, IP-10, and MIG.[Results] In the patient group of definite TB diseases, the positive response rate of QFT was 79%, that of T-SPOT was 88%, and that of IP-10 was 88%. Although there were significant differences among these diagnostic methods, they all yielded highly positive reposnse rates. In the patient group with pulmonary NTM disease including pulmonary M.kansasii, the positive response rate of QFT was 12%, that of T-SPOT.TB was 15%, and that if IP-10 was 13%. There were no significant differences among these diagnostic methods. In the patient group with other respiratory diseases, QFT showed a positive response in two cases, and IP-10 showed a positive response in 1 case. Concerning MIG, the patient group with definite TB diseases demonstrated significantly higher values than those with pulmonary NTM diseases and other respiratory diseases.[Conclusions] Although we estimated the clinical usefulness of IP-10 and MIG to diagnose TB infection, they showed similar positive response rates. Therefore, the combination of these diagnostic methods may increase the diagnostic rate based on this study. ER -