PT - JOURNAL ARTICLE AU - Yanjie Hu AU - Kejing Ying TI - The research on early detection of lung cancer with exhaled volatile organic compounds DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2766 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2766.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2766.full SO - Eur Respir J2014 Sep 01; 44 AB - Breath test might be used as a new mode, non-invasive, and convenient diagnostic method, which can make the assessment of disease through detecting the range of the VOCs exhaled or consumed by the patients, and reflecting the metabolism of the corresponding tissue cell. Considering the location, lung cancer is closely related to VOCs, therefore, to find out the lung cancer-associated specific VOCs might be provided us a new idea and target for early diagnosis of lung cancer.The study confirmed that there are stable conclusion and good repeatability to analyze special VOCs from exhaled breath by SPME-GCMS. We analyzed exhaled breath VOCs of 243 samples by SPME-GCMS system, including 88 samples of lung cancer, 70 samples of lung benign disease, 85 samples of health person, and further researched the sensitivity and specificity of the diagnostic models based on different combinations of special VOCs by applying statistical approaches, such as cluster analysis or stepwise discriminant analysis. In the end, we selected age, as well as 4 to 6 VOCs, as the diagnostic models for lung cancer, including 2,6-dimethylnaphthalene, palmitic aldehyde, nonadecyl alcohol, etc, basically with high sensitivity and specificity more than 85% . Take one model for example, which is consisted of palmitic aldehyde, nonadecyl alcohol, 2,6-dimethylnaphthalene, age, and so on, its specificity is 94.9%, and 78.7% of early stage lung cancer patients were correctly identificated, however, 31.9% of them were misclassificated to advanced stage. The study found that several special VOCs expression are associated with pathological classification, lesion locations, surgery and smoking situation.