RT Journal Article
SR Electronic
T1 Cardiorespiratory response to incremental exercise in asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1768
VO 44
IS Suppl 58
A1 Alice Gicquello
A1 Stéphanie Fry
A1 Rémi Neuvière
A1 Benoit Wallaert
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1768.abstract
AB Background: Asthma is a chronic inflammatory disease with varying severity, ranging from intermittent asthma to severe persistent asthma, and level of disease control. Some patients still report persistent dyspnea despite treatment of asthma. The aim of the study was to assess whether airways obstruction is the only factor explaining dyspnea in asthmatic patients.Methods: 114 asthmatic patients (51.5 years ± 14) were included and divided into two groups: mild tomoderate persistent asthma (group 1, n=79) and severe persistent asthma (group 2, n=35). Spirometry and cardiopulmonary exercise testing were performed (prospective observational study CEPRO 2013-007).Results: View this table:Main results of spirometry and cardiopulmonary testingDespite lower FEV1 in group 2, no difference was observed in aerobic capacity (VO2) between both groups. Respiratory response was different during exercise. In group 2, patients developed a relative hypoventilation and exhausted their ventilatory reserve. In group 1, tachypnea was more pronounced.Conclusion: Exercise breathlessness among asthmatic patients is not related only to bronchial obstruction. In most severe cases, patients developed a respiratory response allowing them to adapt to their disability.