TY - JOUR T1 - Dynamic change of house dust mites and its components- sIgE and sIgG4 in specific immunotherapy JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3471 AU - Peiyan Zheng AU - Baoqing Sun AU - Guangqiao Zeng AU - Wenting Luo AU - Huimin Huang AU - Bao Sun Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3471.abstract N2 - Objectives:The levels of IgE and IgG4 of Der p,Der p1and Der p2 (3 allergens)may change dynamically during Specific immunotherapy (SIT).This project aimed to compare the change of sIgE and sIgG4 before and after SIT, so as to evaluate the potential role of application of SIT in clinical diagnosis.Methods:Serum immune indexes were analyzed from 70 patients with rhinitis and asthma who had already had SIT of standardized Der p.The indicator included the level of sIgE and sIgG4 of 3 allergens in serum in three periods- before treatment(0W),17 weeks after SIT (17W) and 57 weeks after SIT (57W).The dynamic change of sIgE&sIgG4 and correlation between each antibody before and after treatment were analyzedResults:At 17W timepoint , The levels of sIgE of 3 allergens in serum increased continuously.However,at 57W, sIgE decreased significantly again ,which resulted in no difference in sIgE with 0W.The Level of sIgG4 of 3 allergens were observed & recorded in each of three periods, sIgG4 of 3 allergens increased significantly according to the process of treatment. The increasing of the range of Level Der p IgG4 reached the maximum, followed by Der p1 and Der p2. there was also a correlation between sIgE and sIgG4 of Der p and Der p2 in the change of the range of increasement(p<0.05).In each of three periods, the level of sIgE and sIgG4 of 3 allergens in serum in children's group was higher than adults' group. With the process of SIT,sIgG4 of 3 allergens in rhinitis and asthma group was higher than it is in the rhinitis group.Conclusions:The results showed that SIT is a dynamic immune process and Der p with its components sIgE and sIgG4 reflected the immune status in the immune process. ER -