TY - JOUR T1 - Pre-existing cough predicts coughing during endobronchial ultrasound (EBUS) JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3722 AU - Richard Turner AU - James Murray AU - Alice Repossi AU - Sheena Barnett AU - Gillian Tomlinson AU - Manoj Menon AU - Graham Bothamley AU - Angshu Bhowmik Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3722.abstract N2 - Introduction Coughing hinders EBUS and aerosolises secretions. Predictors of cough in bronchoscopy and methods of quantifying it are poorly described.Method Successive patients wore an audio recorder and microphone immediately before, during and after EBUS. Each recording was analysed by one of three authors; half were re-analysed by the main author. Coughs were counted using audio editing software.Results A mean (±SE) of 5.61±1.11 coughs/min were counted during EBUS from 24 patients with cancer (n=13), sarcoid (n=7), tuberculosis (n=2) or reactive mediastinal lymphadenopathy (n=2). The mean disagreement between listeners was 17.8±6.1%. Cough counts were higher in the 12 patients reporting a pre-existing cough (Figure; p=0.05). Coughing during the median (range) 18 (10-100) minutes prior to EBUS was not associated with cough rates during the procedure. There was a trend towards increased cough in the 11 current smokers, as well as those with lung abnormalities on imaging and with cancer, but this was not statistically significant (p=0.30, 0.10 and 0.14, respectively). All received topical lidocaine. There was no evidence of cough suppression in the 17 and 15 patients given 50-100 mcg intravenous fentanyl or 1-4 mg midazolam, respectively.Conclusion Cough frequency in EBUS is highly variable and its measurement difficult although it is higher with pre-existing cough. The influence of medication and other variables remains unclear. ER -