PT - JOURNAL ARTICLE AU - Ottavio Vitelli AU - Alessandra Tabarrini AU - Jole Rabasco AU - Nicoletta Pietropaoli AU - Anna Rita Mazzotta AU - Chiara Romano AU - Martina Forlani AU - Maria Pia Villa TI - Neurocognitive impairment in children with obesity and sleep disordered breathing DP - 2014 Sep 01 TA - European Respiratory Journal PG - P3276 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P3276.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P3276.full SO - Eur Respir J2014 Sep 01; 44 AB - Aims:To compare neurobehavioral disorders in children with Sleep-Disordered Breathing (SDB), with SDB and obesity and in normal controls.Methods:We studied 36 children with SDB (Group 1: M/F 21/15; mean age 8.29±2.04 years, body mass index, BMI, percentile 62,61±29,65), 38 children with SDB and obesity (Group 2: M/F 27/11; mean age 8.73±1.69 years, BMI percentile 116,52±15,95) and 58 non obese control (Group 3: M/F 29/29; mean age 8.89±1.62 years).Groups 1 and 2 underwent clinical evaluation, overnight polysomnography, Attention Deficit/Hyperactivity (ADHD) rating scale and neurocognitive assessment based on Wechsler Intelligence Scale for Children (WISC-R). Group 3 underwent clinical interview and neurocognitive assessment.Results.Verbal Intelligence Quotient (VIQ), Performance Intelligence Quotient (PIQ) and Full-Scale Intelligence Quotient (FSIQ) were lower in groups 1 e 2 than in controls (VIQ 98,11 ± 12,68 vs 91,78±16,11 vs 109,63±12,04; PIQ: 100.63±14.98 vs 93.92±14.89 vs 117.27±11.96; FSIQ: 96.75±13.51 vs 91.81±13.97 vs 114.93±11.05, respectively) (p<0.05).Group 1 and 2 had 5/5 verbal subtest, 2/5 (group 1) and 4/5(group 2) nonverbal subtest significantly lower compared to controls.A positive correlation between PIQ and age of onset of SDB (r= 0,335, p=0,04) was found in group 1. A positive correlation between VIQ and age of onset of SDB (r=0,335, p=0,05) and a negative correlation between VIQ and duration of SDB (r=-0,362, p=0,02) PIQ and BMI percentile (r=-0,341, p=0,03), FSIQ and Apnea/Hypopnea index (r=-0,321, p=0,05) were found in group 2.Group1 had the highest hyperactivity score.Conclusions.Obesity seems to be a cumulative risk factor for cognitive impairment in children with SDB.