PT  - JOURNAL ARTICLE
AU  - Konstantina Kontogianni
AU  - Vasiliki Gerovasili
AU  - Daniela Gompelmann
AU  - Maren Schuhmann
AU  - Philine Kaukel
AU  - Claus Peter Heussel
AU  - Felix J.F. Herth
AU  - Ralf Eberhardt
TI  - Severe heterogeneous emphysema treated unilaterally with endobronchial coils in patients with bilaterally incomplete fissures. Aiming for long lasting endoscopic lung volume reduction (ELVR); is effectiveness sustained at one year follow-up?
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3706
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3706.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3706.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - ELVR with coils has so far been shown to be effective on short term observations.In this retrospective analysis 17 patients with chronic obstructive pulmonary disease ([male]/[female]:10/7, age: 66±7 years), heterogeneous emphysema and incomplete fissures were included. 10 Coils were implanted unilaterally. Patients were followed up at 90 and 365 days after treatment and changes in pulmonary function tests (PFT), 6-Minute-Walk-Test (6MWT) and modified Medical Research Council (mMRC) dyspnea scale were recorded.Results: PFT significantly improved at 90 days but improvement was not sustained at the 365 day follow up; Forced expiratory volume in the 1st second improved at 90 days (0.71±0.14L vs 0.84±0.22L, p:0.02) but at 365 days benefit was lost (0.71±0.14L vs 0.71±0.15L). Similar changes were noted for vital capacity at 90 days (2.2±0.54L vs 2.48±0.81L, p:0.05) and after 365 days (2.2±0.54L vs 2.2±0.71L) and also for residual volume and total lung capacity. 6MWT also improved at 90 days (199±114m vs 251±88m, p:0.003), dropping back at baseline levels after one year (208±108m vs 232±89m) as did mMRC at 90 days (3±1 vs 2±1, p:0.05) losing benefit after one year though(3±1 vs 2±1, p:0.95).Conclusions: Our study shows that unilateral treatment with coils, initially helps improve PFT, exercise capacity and perception of dyspnea up to 90 days post intervention; these benefits are not sustained after one year though. Further large scale studies are needed to assess the long term effects of LVRC and possible benefits of a bilateral treatment.