RT Journal Article
SR Electronic
T1 Effects of prophylactic clarithromycin administration on quality of life in non-CF bronchiectasis patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2541
VO 44
IS Suppl 58
A1 Evangelia Fouka
A1 Stavros Anevlavis
A1 Konstantinos Kaltsas
A1 Antonios Antoniadis
A1 Demosthenes Bouros
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2541.abstract
AB INTRODUCTION: Quality of life (QOL) is impaired in non-CF bronchiectasis. St George Respiratory Questionnaire (SGRQ) can be used as a measure of QOL.AIM: To estimate the efficacy of Clarithromycin prophylaxis on QOL in patients with non-CF bronchiectasis and to evaluate potential associations with sputum bacteriology.SUBJECTS-METHODS: Prospective observational study of 22 adult non-CF bronchiectasis patients suffering from more than 3 infective exacerbations during the previous 12 months. QOL assessments with the SGRQ were performed at baseline and after 24 weeks of daily Clarithromycin administration, 500 mg p.o. Data regarding sputum cultures were also recorded.RESULTS: No sputum bacterial growth was noticed in 9 patients, while P.aeruginosa was isolated in 7 and other bacteria in 6 patients. Post-treatment SGRQ scores decreased significantly, both totally (mean±SEM 29.93±4.32 vs 40.14±4.44,p=0.002) as well as in specific domains (symptoms, activity, impacts: 27.91±5.61 vs 38.79±4.61,p=0.04, 38.36±5.08 vs 51.34±4.88,p<0.001 and 25.57±4.31 vs 34.28±4.89,p=0.01, respectively). SGRQ total scores decreased significantly both in non-colonized and colonized patients (mean±SEM 37.23±5.83 vs 46.74±5.39,p=0.03 and 19.38±4.73 vs 30.72±6.69,p=0.03 respectively), although significant decrease among the latter was noticed only in P.aeruginosa group (mean±SEM 31.85±9.90 vs 47.07±9.47,p=0.015 and 43.51±5.02 vs 46.41±5.08,p=0.368 respectively).DISCUSSION: Our results indicate a favorable effect of Clarithromycin prophylactic administration in QOL in non-CF bronchiectasis, regardless the status of sputum colonization. Patients with P.aeruginosa probably benefit more from the intervention.