RT Journal Article
SR Electronic
T1 Acute exacerbations of chronic obstructive pulmonary disease: Is it acute exacerbations of chronic cardiopulmonary disease?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3604
VO 44
IS Suppl 58
A1 Alizamin Sadigov
A1 Farman Abdullaev
A1 Shamil Aliyev
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P3604.abstract
AB Rationale :Patients with chronic obstructive pulmonary disease(COPD) have elevated cardiovascular risk,an myocardial injury is common during severe exacerbations.Little is know about the elevated cardiac biomarkers and the risk of exacerbations of COPD.Objectives:To investigate how elevated cardiac biomarkers impact to exacerbation rate of the COPD.Methods:We prospectively measured cardiac biomarkers in 68 patients with severe COPD.Fifty-six patients had paired and exacerbation assessments ,repeated at months 1,3,6,9 and 12 during one year.Airway infection was identified using polymerase chain reaction.Measurements and Main Results:COPD exacerbation frequency was related to stable-state elevation of cardiac biomarkers(rho=0.307;p=050).Frequent exacerbators had greater N-terminal pro-BNP than infrequent exacerbators(189.2+_56.9 vs 24.8+_12.7 pg/ml,p<0.001).In those with airway infection at exacerbation(n=34) this rise was greater (202.4+_60.5 vs 160.7+_51.3 pg/ml,p<0.05);prolonged and related to sputum IL-6(rho=o.649;p<0.001).Conclusions:Frequent COPD exacerbators have greater cardiac biomarkers than infrequent exacerbators.Cardiac biomarkers rises actually during COPD exacerbations,particularly with a airway infection.Increasing of cardiac biomarkers are related to inflammation,and are remain stable during observational period.Our study also shown that ,elevated cardiac biomarkers were accompanied with significantly declined lung function and heart dysfunction.