PT  - JOURNAL ARTICLE
AU  - Alizamin Sadigov
AU  - Farman Abdullaev
AU  - Shamil Aliyev
TI  - Acute exacerbations of chronic obstructive pulmonary disease: Is it acute exacerbations of chronic cardiopulmonary disease?
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3604
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3604.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3604.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Rationale :Patients with chronic obstructive pulmonary disease(COPD) have elevated cardiovascular risk,an myocardial injury is common during severe exacerbations.Little is know about the elevated cardiac biomarkers and the risk of exacerbations of COPD.Objectives:To investigate how elevated cardiac biomarkers impact to exacerbation rate of the COPD.Methods:We prospectively measured cardiac biomarkers in 68 patients with severe COPD.Fifty-six patients had paired and exacerbation assessments ,repeated at months 1,3,6,9 and 12 during one year.Airway infection was identified using polymerase chain reaction.Measurements and Main Results:COPD exacerbation frequency was related to stable-state elevation of cardiac biomarkers(rho=0.307;p=050).Frequent exacerbators had greater N-terminal pro-BNP than infrequent exacerbators(189.2+_56.9 vs 24.8+_12.7 pg/ml,p<0.001).In those with airway infection at exacerbation(n=34) this rise was greater (202.4+_60.5 vs 160.7+_51.3 pg/ml,p<0.05);prolonged and related to sputum IL-6(rho=o.649;p<0.001).Conclusions:Frequent COPD exacerbators have greater cardiac biomarkers than infrequent exacerbators.Cardiac biomarkers rises actually during COPD exacerbations,particularly with a airway infection.Increasing of cardiac biomarkers are related to inflammation,and are remain stable during observational period.Our study also shown that ,elevated cardiac biomarkers were accompanied with significantly declined lung function and heart dysfunction.