TY - JOUR T1 - The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2712 AU - Ender Coskunpinar AU - Nergiz Akkaya AU - Pinar Yildiz AU - Yasemin Musteri Oltulu AU - Engin Aynaci AU - Turgay Isbir AU - Ilhan Yaylim Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2712.abstract N2 - The aim of our study was to investigate HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in patients with NSCLC. In this study, 97 patients with NSCLC and 97 healthy controls were included. RT-PCR technique was used for genotyping. The frequency of mutant CC genotype for HSP90AA1, mutant AA genotype for HSP90AB1 and mutant CC genotype for HSP90B1 was significantly higher in the patient group in controls. The frequency of patients with homozygote mutant allele was also significantly higher than that of controls and possessing mutant genotype increased appears to be the risk for diseaseView this table:Results of the haplotype analysis in patients and controls (HSP90AA1, HSP90AB1 and HSP90B1 genes). We detected that presence of mutant genotype [all included HSP90AA1, HSP90AB1, HSP90B1] increase the risk for diseaseView this table:Probabilty of associations have been shown in the table as a comparison of patients and controls. ER -