PT  - JOURNAL ARTICLE
AU  - Lilach Kleinberg
AU  - Peter Jebsen
AU  - Marius Lund-Iversen
AU  - Åslaug Helland
AU  - Lars Fjellbirkeland
TI  - EGFR-mutated lunge cancer in a general Norwegian population
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2746
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2746.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2746.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: The frequency of activating EGFR-mutations in lung cancer in Caucasians, has been said to be 15% in adenocarcinomas (AC) and very low in squamous-cell-carcinoma (SCC). From January 2011 to December 2012 the Norwegian policy was to test all NSCLC on a reflexive basis irrespective of histological subtype.Methods: As part of a retrospective study we wanted to find the frequency of this mutation in an unbiased selection of NSCLC-patients. All tests performed at Oslo University hospital (OUH) in 2011-12 were examined. OUH does about 40% of all testing in Norway.Results: A total of 1245 patients were tested, 55,3% men and 44,7% women. Immunohistochemistry was performed on 61% of all the specimens to help classifying the subtype of NSCLC. The histologic diagnosis was AC in 775 patients (62,3%) and SCC in 304 (24,4%). The rest had either unspecified NSCLC (8,8%), large-cell carcinoma (LCC)(2,4%) or unknown histology (2,1%). The tissue specimens came from biopsies in 68% of cases, cytology in 12% and the rest, 20%, were resections. Activating EGFR-mutations were found in 83 patients (6,7%) while no mutations were seen in 91,8%. In 19 patients, 1,5%, the tests were inconclusive. Among men 4,9% were positive and in women 8,8% were mutation positive. In AC the frequency of mutations was 10,1% (8,4% for men and 11,9% for women). Only one mutated SCC was seen, in a woman. In unspecified NSCLC, 3 patients (3,6%) had the mutation. None of the LCC tested positive.Conclusions: In our population the frequency was lower than expected from former studies. All but four cases were AC. The frequency was higher among women than men.