@article {Koplin4904, author = {J Koplin and C Janson and E Omenaas and L Br{\"a}back and T Gislason and R J{\"o}gi and V Schl{\"u}nssen and K Tor{\'e}n and A Johannessen and C Svanes}, title = {Late-breaking abstract: Change in prevalence of asthma phenotypes in two generations born 1945-2000}, volume = {44}, number = {Suppl 58}, elocation-id = {4904}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Increasing population prevalence of asthma over the last decades is well known, but there is limited knowledge on time trends of asthma phenotypes over a long time span. We studied changes in prevalence of asthma phenotypes by birth year in a cohort born 1945-75 and their offspring born 1965-2000. The population-based, multi-centre RHINE III study included 13499 responders from Northern Europe, and assessed asthma for 20713 offspring age 10-51 years. Multi-level logistic regressions of asthma phenotypes (childhood ({\textexclamdown}{\"U}10 years) and later onset (10-30 years)) were adjusted for study centre, offspring analyses also for parental asthma and sex, and clustering by family. Childhood asthma increased by birth year from 1945 to 2000 (Figure 1). Parents and offspring born 1965-75 had similar prevalence. The prevalence increased slowly for the parent generation born 1945-75 (OR per 5 years 1.13 [95\%CI 1.05-1.22]), and more rapidly for the offspring generation born 1975-2000 (1.30 [1.25-1.36]). This increase was seen in all centres. Later onset asthma increased by birth year in parents (1.35[1.26-1.45]), but did not increase in offspring born 1965-85. Conclusion: Childhood onset asthma increased by birth cohort from 1945 to 2000, more rapidly since the 1970s. Policy makers need to be aware of the large cohorts entering adulthood with a history of asthma.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/4904}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }