TY - JOUR T1 - Analysis of multidrug-resistant tuberculosis JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2646 AU - Rashidah Yasin AU - Zamzurina Abu Bakar AU - Abdul Razak Abdul Muttalif Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2646.abstract N2 - Introduction: Multidrug-resistant tuberculosis (MDRTB) is a major problem in TB control program globally. The incidence of MDRTB in Malaysia is increasing over last few years. The outcome is worse compared to pan susceptible TB.Objectives: The objectives are to determine the demographic characteristics and describe the outcomes of MDRTB patients in our center.Methods: A retrospective study of MDRTB diagnosed in Institute of Respiratory Medicine, Kuala Lumpur. Patients were identified based on sputum mycobacterium culture and sensitivity records from June 2007 to June 2013 and data were collected from patients' notes.Results: Total numbers of MDRTB cases diagnosed during the periods were 87. The median age was 37 (IQR 22), ranges from 14 to 61 years old. Two third (66.7%) of cases were male. 43 (49.4%) were Malaysian and 44 (50.6%) foreign born. Majority of patients were Myanmar's (36.8%), followed by the Malays (29.9%). The majority of MDRTB cases were acquired (65.5%). All patients received second line therapy. Out of 87 cases, 34.5% cured, 21.8% defaulted treatment, 16.1% transferred out, 8.1% died and 19.5% on treatment. We found significant correlation between severity of radiological findings, disease complications and duration of symptoms with the patients' outcome (P<0.001, P<0.001 and P=0.029 respectively) as we compared groups of cured and died. However, the pattern of drugs resistant and the regimen of second line treatment were not correlated with the outcome (P=0.223 and P=0.851).Conclusion: Our result demonstrated that the majority of MDRTB cases were acquired. The cured rate in studied cohort was 34.5%. Advanced radiological findings, disease complications and prolonged symptoms were associated with poor outcome. ER -