PT  - JOURNAL ARTICLE
AU  - Ercan Kurtipek
AU  - Zafer Büyükterzi
AU  - Meral Büyükterzi
AU  - Mehmet Sertaç Alpaydin
AU  - Taha Tahir Bekci
AU  - Bengi Akin
AU  - Sami Erdem
TI  - Endothelial dysfunction in pulmonary embolism: Neutrophil-lymphocyte and platelet-lymphocyte ratio
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2395
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2395.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2395.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Pulmonary Embolism (PE) is a frequent urgent cardiovascular situation. Recent studies have shown activated leucocytes form oxygen radicals leading to endothelial destruction and thus to increased inflammation risk and thrombogenesis. The aim of the present study is to show possible endothelial dysfunction and subclinical atherosclerosis in PE patients.71 acute PE patients, diagnosed at the emergency and chest department at Konya Education and Research Hospital, with a mean age of 64.94 ± 15.27 and 83 healthy individuals with a mean age of 63.53 ± 19.15 were included in the present study. Flow-Mediated-Dilatation (FMD) and Carotid Intima Media Thickness (CIMT) as well as Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) were measured. According to the data obtained, there were significant increases in the NLR and PLR levels in the PE group (p<0.05)View this table:Table-1. The Result of NLR and PLR levels. Furthermore, the FMD and CIMT levels increased significantly in the PE group (p<0.05)View this table:Table-2. The Result of CIMT and FMD levels.The findings of the present study suggest that endothelial dysfunction and subclinical atherosclerosis in PE patients may have a role in mortality.