PT  - JOURNAL ARTICLE
AU  - Riccardo Inchingolo
AU  - Andrea Smargiassi
AU  - Giuliana Pasciuto
AU  - Giuseppe Corbo
AU  - Manuela Cavalletti
AU  - Giuliano Montemurro
AU  - Daniele Magnini
AU  - Giancarlo Scoppettuolo
AU  - Riccardo Torelli
AU  - Teresa Spanu
AU  - Maurizio Sanguinetti
AU  - Salvatore Valente
TI  - Venous central line catheter management in respiratory semi-intensive care unit: The way to zero central line-associated bloodstream infections (CLABSIs) – A randomized controlled trial
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P255
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P255.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P255.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Aims: 1) efficacy of educational interventions on rate of CLABSIs, 2) effects of port protector, 3) rate of contamination.9months of observation and 9months of interventional period. We enrolled patients with CVC: 1) placed in RSICU, 2) previously placed without signs of SIRS during 48h before of admittance, 3) previously placed without microbiological evidence of colonization.During interventional period we randomized patients into two groups: 1) educational intervention plus port protector (Group 1) and 2) educational intervention (Group 2). Patients developing SIRS underwent both peripheral and central blood cultures. We identified 5 conditions: 1) CVC-related sepsis (both blood cultures positive with differential time to CVC positivity at least 2h before); 2) CVC not related sepsis (both blood cultures positive with: a) differential time to CVC positivity less than 2h or b) peripheral positivity precedes CVC one); 3) CVC colonization; 4) contamination of peripheral blood culture; 5) central and peripheral blood cultures negativity.87 CVC were included during observational period. Catheter dwell time was 1068. CLABSIs rate was 8.4/1000. 10 sepsis (9 CLABSIs), 16 CVC colonization and 6 contamination of blood cultures were observed. 46 CVC were included during interventional period. Catheter dwell time was 707. CLABSIs rate was 1.4/1000. 21/46 CVC were included into Group 1. 5 CVC colonization (2 in Group 1), 3 contamination of blood cultures (only in Group 2) were observed. In Group 1 no CLABSIs were reported.Both kinds of interventions significantly reduce the rate of CLABSIs.