PT - JOURNAL ARTICLE AU - Julia Fresenius AU - Fabian Fohrer AU - Werner von Wulffen AU - Nikolaus Kneidinger AU - Rene Schramm AU - Hauke Winter AU - Lorenz Frey AU - Jürgen Behr AU - Claus Neurohr TI - Lung transplantation and coronary artery disease - a relative contraindication? DP - 2014 Sep 01 TA - European Respiratory Journal PG - P263 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P263.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P263.full SO - Eur Respir J2014 Sep 01; 44 AB - IntroductionThe diagnosis of coronary artery disease (CAD) is considered as a relative contraindication for lung transplantation.Aims and ObjectivesThe aim of this study is to examine the mortality of patients with diagnosed CAD and normal left ventricular function and patients with excluded CAD before lung transplantation.MethodsA retrospective analysis of all lung transplantations at LMU Munich between 1998 and 2012 was performed.Results328 coronary angiographies were performed before lung transplantation (127 patients with COPD, 174 patients with Interstitial Lung Disease and 27 patients with other diagnosis). All patients have a normal left ventricular function with an EF over 60%. 254 patients (77.4%) had coronary angiography without any pathological finding. In 74 patients (22.6%) a stenosis of 40 % or higher was found in at least one vessel with good left ventricular function. 54 of the 74 CAD-patients (73%) obtained a conservative therapy. The remaining 20 patients (27%) needed additional interventional therapy (PCI with stent implantation).Patients with CAD had a significant higher mortality after 1, 3 and 5 years compared to patients without CAD (p= 0.07; 0.01; 0.02 respectively). There is no significant difference in the mortality between the conservative and the interventional treated CAD patients. Perioperative bleeding complications could be detected in 11.1% of the CAD patients and in 5.5 % of the patients without CAD. Multivariate regression analysis revealed, CAD is a risk factor for mortality independent of age and the type of transplantation.ConclusionsOur data suggest, the coronary artery disease influence outcome after lung transplantation.