TY - JOUR T1 - Late-breaking abstract: Increased risk of asthma in overweight children born large-for-gestational-age JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1241 AU - Leonardo Pinto AU - Stefano Guerra AU - Josep Maria Anto AU - Dirkje Postma AU - Gerard Koppelman AU - Johan de Jongste AU - Ulrike Gehring AU - Henriette Smit AU - Alet Wijga Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1241.abstract N2 - Background: There is evidence suggesting that fetal growth influences the risk of asthma. Being born large-for-gestational-age (LGA) is a well-known marker of increased growth velocity in fetal life. However, the effect of being LGA on the atopic and nonatopic asthma remains unknown.Objective: To investigate the impact of being born LGA on asthma in school-age children, and potential modifications of the association by weight or atopy.Methods: For 1,697 participants of the PIAMA birth cohort data on asthma, and measurements of anthropometry and atopic sensitization at age 8 years were available. Relative risks for the association between asthma and being LGA were estimated by logistic regression adjusting for possible confounders. Potential effect modifications by overweight and atopic sensitization were explored in stratified analyses.Results: The combination of being born LGA with overweight at age 8 years was associated with an increased risk of asthma (OR 2.76; CI 1.36-5.60) in particular an increased risk of nonatopic asthma (OR 5.88; CI 2.30-15.06). In this study, we have identified two important effect modifiers that influence the association between neonatal size and asthma: current overweight and atopic sensitization.Conclusions: This study describes effect modifiers that influence the relationship between being born LGA and asthma. The combination of being born LGA and having current overweight is a risk factor of asthma at age 8 years, especially in nonatopic children. Improved knowledge on the association between LGA, obesity and asthma can be used for prevention, considering that LGA is early life risk factor that may identify high risk subjects. ER -