@article {O{\textquoteright}ReillyP1986, author = {Liam O{\textquoteright}Reilly and Elizabeth Sapey and Sebastian Desando and James Stockely and Robert Stockley and Brendan Cooper}, title = {The effect of posture on ventilation using SLP in healthy subject and patients with Alpha 1 anti-trypsin deficiency (A1AT)}, volume = {44}, number = {Suppl 58}, elocation-id = {P1986}, year = {2014}, publisher = {European Respiratory Society}, abstract = {IntroductionStructured Light Plethysmography (SLP) can show changes in ventilatory patterns by using relative thoracic contribution (RTC) inspiration to expiration ratio (IE50), inspiration time (Ti), inspiration and exhalation flux (Ti/Ttot) \& breathing asynchrony by phase angle (PA).AimsTo measure the change in breathing patterns by SLP from sitting to supine in healthy controls (HC) and patients with A1AT.MethodsWe measured respiratory signals using Thor3Di (PneumaCare, Cambridge, UK) in 23 A1AT patients Mean (SD); 16M:11F, Age: 56.0 (10.4) years, 26.4 (4.9) BMI; FEV1 SR: -2.10 (2.26) ) and 16 healthy controls (5M:11F, 34.6 (8.4) years, Age: 24.6 (4.3) BMI; FEV1 SR: 1.92 (0.74) ) both sitting and supine for 1-2 minutes and analysed using Mann-Whitney tests.ResultsChanges seen in IE50 \& Ti/Ttot when supine, between sitting and supine in both patients and controls, but there were no differences between the patients \& healthy subjects.View this table:Discussion: 12 of the patients had lung disease and further analysis of this subset may show differences in respiratory patterns. There was little difference in the two groups of subjects despite the large age difference.ConclusionThere was no overall difference in breathing patterns sitting and supine between the patients and healthy controls.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P1986}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }