TY - JOUR T1 - Relation between pulmonary arterial remodeling and parenchymal disease in severe COPD and interstitial lung disease patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2340 AU - Berta Sáez AU - Juan Grignola AU - Manuel López Meseguer AU - Enrique Domingo AU - Cristina Berastegui AU - Carlos Bravo AU - Antonio Roman Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2340.abstract N2 - Pulmonary vasculopathy relation with lung function is analyzed in COPD and interstitial lung disease (ILD) candidates for lung transplantation (LT) with precapillary pulmonary hypertension (PH).106 patients (p) preLT, NYHA 3-4, 41 COPD (59±5 yo, 9 fem), 65 ILD (60±7 yo, 19 fem) were studied with right heart catheterization and IVUS in medium sized pulmonary arteries (PA). Pulmonary hemodynamics, local PA elastic modulus (EM: diastolic lumen area x pulse pressure/(systolic-diastolic lumen area)) and lung function tests were collected.View this table:Characterictics of the population16% had wedge pressure ≥ 15 mmHg and were excluded. 48% COPD and 43% ILP had PH. EM was obtained in 18/31 COPD and 28/58 ILD. Arterial oxygen pressure was inversely correlated with mPAP in both, COPD (r=-0.44, p<0.01) and ILD (r=-0.35, p<0.01). ILD had higher EM than COPD (p<0.05). FEV1 and EM correlated in COPD but FVC and EM did not correlate in ILD. Neither FEV1 nor CVF correlated with mPAP.COPD and ILD have different pulmonary vasculopathy. Only COPD correlated parenchymal and vascular disease in the presence of PH, suggesting different pathogenic pathways of PH and vascular remodeling in both diseases. ER -