TY - JOUR T1 - The effects of oral care on FeNO measurement in asthmatic patients JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P989 AU - Mitsuhiro Kamimura AU - Yoichiro Hamamoto AU - Atsuto Mouri AU - Munehisa Hukusumi AU - Tatsuya Ibe Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P989.abstract N2 - [Background] The fractional exhaled NO (FeNO) is widely measured as an indicator of bronchial inflammation in asthmatic patients. However, No is also produced in the oral cavity, though it is minor component of total FeNO. In oral cavity, nitrate in saliva is reduced into NO by anaerobes and acid circumstance. Thus, the amount of oral NO production might depend on local condition. We evaluated the influence of oral care on the measurement of FeNO in patients with asthma.[Patients and Methods] Sixty-two patients with asthma were enrolled in the study. At their visit to the out-patient department of the hospital, FeNO was measured before and after the oral care by 3 minutes teeth brushing and gargling with water. NIOX MINO was used for FeNO measurement.[Results] In total cases, before the oral care, FeNO was 26.7+/-27.1ppb and after the oral care, 25.0 +/- 27.5ppb. The FeNO decreased by 1.73+/-0.95 (-31∼+23, p=P=0.0090 Wilcoxon signed-rank test) after the oral care.In the group in which the FeNO level is above 20ppb before the oral care (n=28), FeNO decreased by 3.14+/-1.98 (P=0.0120) and above 30ppb (n=15), 5.467+/-3.10 (P=0.0123) after the oral care. The Higher the FeNO level before the oral care, the larger the decrease of the FeNO level. The decrease of FeNO by the oral care significantly co-related with higher age (p=0.0243).[Conclusions] FeNO decreased significantly by the oral care. In total cases, its impact is limited but there would be high oral NO producers among those with higher age and with those with higher FeNO level at the baseline. The oral origin NO should be taken into count when FeNO level is not co-related with the symptom activities. ER -