PT - JOURNAL ARTICLE AU - Olga Kharevich AU - Irina Lapteva AU - Elena Lapteva TI - Factors associated with irreversible airway obstruction in patients with asthma DP - 2014 Sep 01 TA - European Respiratory Journal PG - P1760 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P1760.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P1760.full SO - Eur Respir J2014 Sep 01; 44 AB - Introduction. Significant proportion of patients with asthma has irreversible airway obstruction (IAO) despite the adequate treatment.The aim of the study was to reveal predictors of IAO in asthma patients.Methods. Data from 141 adult patients with asthma were evaluated (38 males, 103 females, age 52.5±12.0 years, asthma duration 13.3±12.2 years). Patients with COPD, smoking history (≥10 pack-year) were not included. 78 patients (55%) had IAO defined as postbronhodilator FEV1/FVC≤70% pred. and/or postbronhodilator FEV1≤80% pred. Multivariate logistic regression was performed to identify factors associated with IAO in asthma.Results. As compared with the patients with reversible airway obstruction or without obstruction, patients with IAO were older, more likely males, suffered from more severe disease, had longer disease duration, more frequent exacerbations and had history of allergic conditions less often. These parameters were included in multivariate logistic regression model. Continuous variables were previously dichotomized. The factors independently associated with presence of IAO were as follows: severe asthma (OR, 3.7; 95% CI, 1.41 to 9.59, p=0.007), male gender (OR, 5.2; 95% CI, 1.8 to 14.8, p=0.002) and disease duration >20 years (OR, 5.3; 95% CI, 1.8 to 16.1, p=0.003). History of allergic conditions was protective factor for IAO in asthma (OR, 0.38; 95% CI, 0.16 to 0.88, p=0.023).Conclusion. Male patients with severe asthma and longer disease duration without history of allergic conditions are more likely to develop IAO. The occurrence of IAO in substantial part of asthma patients and its relations with some clinical and demographic parameters suggests heterogeneity of the disease.