TY - JOUR T1 - Serum YKL-40 level is associated with apnea hypopnea index in patients with obstructive sleep apnea syndrome JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1531 AU - Levent Cem Mutlu AU - Feti Tülübas AU - Recep Alp AU - Gizem Kaplan AU - Zeynep Deniz Mut AU - Ahmet Gürel Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1531.abstract N2 - IntroductionObstructive sleep apnea syndrome (OSAS) has been associated with elevations in biochemical markers of inflammation. Although the exact mechanism is not known, both sleep deprivation and hypoxemia are believed to be important causative factors. YKL-40, also known as chitinase-like protein was shown to be related with various inflammatory conditions including atherosclerosis, diabetes, cancer and asthma.The aim of the study was to evaluate the relationship between YKL-40 levels and apnea hypopnea index in patients with obstructive sleep apnea syndrome.Methods:The study was conducted in the sleep unit of Namik Kemal University research center. From January 2013 to December 2013, 120 patients diagnosed with OSAS by polisomnography and 40 age, sex, and body mass index (BMI) matched subjects, with AHI < 5 were recruited.The OSAS patients were further divided into mild, moderate and severe groups based on AHI. Serum YKL-40 concentrations were measured by Enzyme-Linked Immuno Sorbent Assay (ELISA).ResultsYKL-40 levels were signifiacantly elevated in OSAS patients than control group, Serum YKL-40 levels were found 97,3 ± 19,09 pg/ml in control group, 124,11± 47,97 pg/ml in mild,:169;39 ± 9,42 pg/ml in moderate and 174;78±77,46pg/ml in severe group. Spearman correlation analysis showed that serum YKL-40 levels were significantly and positively correlated with AHI (r = 0,434, p< 0.001).ConclusionThe study demonstrated that high serum YKL-40 levels were correlated to severity of OSAS and could be a biomarker for predicting and progression of the disease. ER -