RT Journal Article SR Electronic T1 Multidimensional evaluation of dyspnea in COPD: An observational field-study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2182 VO 44 IS Suppl 58 A1 Capucine Morelot-Panzini A1 Hélène Gilet A1 Bernard Aguilaniu A1 Benoit Arnould A1 Philippe Devillier A1 Alain Didier A1 Thierry Perez A1 Thomas Similowski YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2182.abstract AB Dyspnea in COPD is a major negative driver of quality of life (QoL). The impact of dyspnea on QoL derives from dyspnea-related reduction in exercise tolerance, with emphasis on perceptual factors as determinants of exercise cessation. Yet dyspnea, like pain, is multidimensional with sensory (S) and affective (A) components. We described the relationship of S and A with patient related outcomes (PROs) and COPD characteristics related to A. We studied 276 stable patients, recruited by 74 physicians at the time of a therapeutic adjustment (age 66.4; FEV1 44.8; FRC 149.4; GOLD 2,3,4: 34, 36, 30%; GOLD ABCD: 8, 20, 8, 64%; cardiovascular comordidity 56%; exacerbations in past year: 144 patients, 1.8 event). The main outcome was the multimensional dyspnea profile (MDP) scored according to Meek (Chest 2012,141,1546). MDP showed good multi-trait validity and internal consistency (Cronbach's alpha > 0.8). Concurrent validity analysis showed that S was better correlated with MMRC, CAT, and the DIRECT handicap score than A. Conversely, A was better correlated to SF 12-mental, the HADS-anxiety, and K6 general mental state score than S. S linearly increased with MMRC and patients' self-assessment of health status, whereas A exhibited a disproportionate increase for MMRC grade IV and the most severe values of health self-assessment. Multivariate analysis showed that A was significantly related to FEV1, depressive clinical elements, and type of physical activity (A more important when activity limited to household). In conclusion: 1) MDP has good psychometric qualities in COPD; 2) separating S and A is feasible in a field setting; 3) S and A have different impact on PROs in COPD patients. Supported by Pierre Fabre.