RT Journal Article SR Electronic T1 Development of the Manchester sleep symptoms index in COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2018 VO 44 IS Suppl 58 A1 Janelle Yorke A1 Adam Garrow A1 Matt Khan A1 Sarah Tyson A1 Dave Singh A1 Jorgen Vestbo YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2018.abstract AB Aim: In COPD disturbed sleep is related to exacerbation frequency, quality of life and mortality. We developed the Manchester Sleep Symptoms Index-COPD (MSSI-C) to assess night-time symptoms and disturbed sleep. Methods: Identification of potential items was guided by qualitative work with COPD patients and age-matched controls. COPD specific and general symptoms items were retained. A cross-sectional study then identified items for final inclusion. Hierarchical methods and Rasch analysis were used to inform item deletion and the development of a unidimensional scale. Internal consistency and test-retest reliability were assessed. Concurrent validity was examined using Pearson's correlation with the St George's Respiratory Questionnaire (SGRQ). Results: Qualitative data from 45 patients with COPD and 12 age-matched controls informed the initial 22 item-list. The cross-sectional study included 204 patients (GOLD: 1: 17% 2:48% 3:26% 4: 9%; male 62%, mean age 65 sd 7 years) and 54 age-matched controls (mean age 68 sd 5 years, male 50%). 11 items were removed during hierarchical methods and a further 4 due to similar responses between COPD and non-COPD groups. The final MSSI-C contains items relating to falling asleep and night-time awakening: breathlessness, chest tightness, cough and sputum. The MSSI-C demonstrated good internal consistency (Cronbach's alpha 0.9) and test-retest repeatability (>0.7). MSSI-C scores significantly correlated with the SGRQ (Symptoms: r=0.59; Impacts: r=0.60; Activity: r=0.38). Conclusion: The MSSI-C shows good preliminary reliability and validity, and should lead to a better understanding of the impact that symptoms specific to COPD have on sleep outcomes.