@article {JohalP955, author = {Baljinder Johal and John Tuohy and Jonathan Marshall}, title = {Plume temperature and force of fluticasone propionate/formoterol pMDI compared with fluticasone propionate/salmeterol pMDI}, volume = {44}, number = {Suppl 58}, elocation-id = {P955}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background:Aerosol inhaler characteristics such as low plume temperature and high force may result in greater impaction of drug in the mouth and throat and reduced lung deposition.1 This study compared plume temperature and force of two ICS/LABA combination products: fluticasone propionate/formoterol 125/5μg (FP/FORM; flutiform{\textregistered}) and fluticasone propionate/salmeterol 125/25μg (FP/SAL; Seretide{\textregistered}), delivered via metered-dose inhalers.Methods:Inhalers were held in a fixed device and operated according to manufacturers{\textquoteright} instructions. A thermal imaging video camera, operating at 30 frames per second, recorded plume temperature from the side of the device. The same test rig, with a copper disc attached to a sensitive load cell measured plume force over a range of distances 25mm to 95mm from the device.Results:At 25mm the FP/FORM plume was +6oC, while that of the FP/SAL plume was -38oC. The FP/SAL plume was colder over a longer distance. The force of the FP/SAL plume was greater than that of the FP/FORM device at all distances measured: mean force recorded for FP/SAL was 218.0mN compared to 104.0mN for FP/FORM.Conclusion:The FP/SAL plume was considerably colder than the FP/FORM plume particularly over shorter distances. The FP/SAL plume was more forceful, approximately twice that of the FP/FORM device. These differences may be due to different types of HFA propellant with different boiling points, the excipients in each formulation, and actuator geometry. The plume characteristics of the FP/FORM device may facilitate lung deposition and lessen impaction in the throat.1 Gabrio BJ. Int J Pharm 1999;186:3-12Sponsor: Mundipharma Research Ltd.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P955}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }