@article {AudagP1233, author = {Nicolas Audag and Dimitri Van der Linden and Fran{\c c}oise Smets and Xavier Stephenne and Etienne Sokal and Gr{\'e}gory Reychler}, title = {Comparison of pentamidine inhaled dose with two different nebulizers}, volume = {44}, number = {Suppl 58}, elocation-id = {P1233}, year = {2014}, publisher = {European Respiratory Society}, abstract = {INTRODUCTION: Nebulized pentamidine is used in the prevention of pneumocystis carinii pneumonia in immunosuppressed patients. A specific nebulizer with characteristics to ensure deep lung deposition is required. It must include a circuit with expiratory filter preventing the dissemination of droplets into the environment. The reference nebulizer for pentamidine delivery is the Respirgard II{\textregistered}. All nebulizers with comparable properties could be used for the nebulization.AIMS AND OBJECTIVES: The aim of this work was to evaluate and to compare the inhaled dose between the Respirgard II{\textregistered} and the Isoneb{\textregistered}.METHODS: The nebulizers were connected to a dual chamber lung model (5600i Dual Adult Training/Test Lung{\textregistered}, Michigan Instrument Inc.) simulating usual breathing pattern of an adult patient. A solution of pentamidine (300mg/6mL sterile water) was nebulized during 20 minutes. We measured in triplicate the inhaled dose by weighting the filter positioned between the nebulizer and the test lung. We measured also the residual solution by weighting the cup of nebulizers before and directly after nebulization. The residual dose was obtained by subtracting the inhaled dose from the nominal dose.RESULTS: There is no significant difference in the inhaled dose (p = 0.611). The residual solution in the nebulizer cup is greater with Respirgard II{\textregistered} (p= 0.0363) but we find no significant difference in residual dose (p= 0.611).CONCLUSION: We observed that the inhaled dose is similar with the two nebulizers.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P1233}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }