RT Journal Article SR Electronic T1 Functional independence, symptoms, quality of life and emotional responses after pulmonary rehabilitation in COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P600 VO 44 IS Suppl 58 A1 Francesca Moretti A1 Guido Vagheggini A1 Stefano Mazzoleni A1 Giulia Montagnani A1 Eugenia Panait Vlad A1 Pier Paolo Cavicchioli A1 Giulia Farru A1 Luca Pantani A1 Daniele Berrighi A1 Lorenzo Buono A1 Nicolino Ambrosino YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P600.abstract AB Background and aim: Functional independence Measure (FIM), has been recently included among the outcome measures of pulmonary rehabilitation (PR). Aim of the study was to analyze relationships between changes in FIM and quality of life after PR in COPD patients.Materials and methods:We prospectively enrolled 55 COPD patients (26m; age 72.3±8.5years) consecutively undergoing an inpatient PR program after an episode of severe acute exacerbation between September 2012 to September 2013. Medical Research Council (MRC) dyspnea, FIM, Copd Assessment Test (CAT) and St. George's Respiratory Questionnaire (SRGQ), Beck Depression Inventory (BD) and State-Trait Anxiety Inventory (STAI) scores were assessed at admission and at the end of PR. The subjects were divided into two subgroups (SG1 and SG2) according to the median value (MV) of FIM change (SG1<, SG2≥MV).Results: Four patients were excluded from data analysis (3 deceased, 1 transferred). After PR whole group improved in MRC (2.9±0.8 to 2.0±0.9; p=0.000), FIM (97.2±25.7 to 105.0±23.1; p=0.002) SGRQ (44.0±17.3 to 32.5±16.8; p=0.000), and CAT (19.0±7.0 to 14.5±6.0; p=0.000) scores, and in Six-minute walking distance (219.7±102.0m to 275.2±123.6m; p=0.000). FIM change MV was 6. SG1 and SG2 were homogeneous by age and gender. SG1 showed higher PaCO2 and HCO3, and lower FIM at pre-PR. No significant differences on quality of life (CAT, SGRQ) and emotional status were observed between SG1 and SG2, both at pre- and post-PR.Conclusions: Improvement in functional independence is higher in patients more severely impaired in activities of daily living. Changes in FIM are not related to changes in perceived quality of life.