RT Journal Article
SR Electronic
T1 Aerobic exercise inhibits pseudomonas aeruginosa-induced acute lung injury in elderly mice
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 481
VO 44
IS Suppl 58
A1 Flavia Regina Greiffo
A1 Thomas Stravinskas Durigon
A1 Juliana Moreno Guerra
A1 Joao Paulo Pedroso
A1 Danielle Silva Dias
A1 Christiane Malfitano
A1 Katia de Angelis
A1 Flavio Aimbire
A1 Nilsa Regina Damaceno-Rodrigues
A1 Iris Takako Moribe
A1 Edison Luiz Durigon
A1 Regiane Albertini
A1 Ana Paula Ligeiro de Oliveira
A1 Rodolfo Paula Vieira
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/481.abstract
AB The pseudomonas aeruginosa is a common opportunistic pathogen that can lead to death, especially to immunossupressed population, as elderly. Regular aerobic training (AT) improves lung response in pulmonary diseases and also the immune system. Therefore, this study investigated the possible protective effects of low intensity AT on the pulmonary inflammatory and immunological response in a model of acute lung injury induced by pseudomonas aeruginosa in elderly mice. The low intensity treadmill AT was performed during 4 weeks, 1 h/session, 4x/week in 24 weeks old C57Bl/6 male mice. Twenty-four hours after last AT session, mice were inoculated with 5 x 104 colony units of pseudomonas aeruginosa and were analyzed 24 hours after that. The results demonstrated that AT significantly reduced pseudomonas aeruginosa increased the numbers of total cells (p<0.01) and neutrophils (p<0.01) in the bronchoalveolar lavage (BAL) and the number of neutrophils in the lung parenchyma (p<0.01) when compared with pseudomonas group. The results also showed that AT reduced the levels of IL-1beta, IL-6, KC and TNF-alpha, while increased the levels of IL-10 in BAL (p<0.01) when compared with pseudomonas group. AT also increased the expression of IL-10 and reduced the expression of NF-kB in the lung when compared with pseudomonas group (p<0.01). In addtion, AT also increased the levels of catalase, glutatione peroxidase, superoxide dismutase and decreased the levels of lipoperoxidation in the lungs when compared with pseudomonas group (p<0.05). We conclude that AT inhibits acute lung injury induced by pseudomonas aeruginosa in ederly mice, through a IL-10/NF-kB/antioxidant-dependent mechanism.