RT Journal Article SR Electronic T1 Muscular fat as a cardio-metabolic modulator in COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4827 VO 44 IS Suppl 58 A1 Isabelle Vivodtzev A1 Luc Montcharmont A1 Renaud Tamisier A1 Clémence Minet A1 Jean-Christian Borel A1 Patrick Lévy A1 Gilbert Ferretti A1 Jean-Louis Pépin YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/4827.abstract AB Background: Loss of peripheral skeletal muscle mass and excessive fat accumulation have been associated with cardiometabolic morbidity and mortality in COPD. We aimed at identifying the role of skeletal muscle fat infiltration on cardiometabolic surrogate risk factors in COPD.Methods: 78 COPD (64 ± 9 years) were prospectively included and assessed using metabolic and inflammatory biological parameters as well as subclinical markers of cardiovascular risk (arterial stiffness and endothelial function). Tertiles of body mass index (BMI) (Low [15<BMI≤23], middle [23<BMI≤28] and high [28<BMI≤36] kg/m2) were used for comparison in mid-thigh quadriceps muscle volume and percent of muscle fat infiltration (MFI=intramuscular fat volume/[intramuscular fat volume+ muscle volume]) measured by CT scan (automatic segmentation :-190 to -30; -30 to +30 and +30 to +70 Hounsfield Units for fat, intramuscular fat and muscle, respectively, in a 4-cm height).Results: The highest BMI COPD tertile showed higher intramuscular fat volume that corresponded to 52 [43; 60]% of total muscle volume vs. 47 [38; 55]% and 34 [29; 38]% in middle and low BMI groups, respectively, p <0.0001. A high muscle volume was associated with lower NT-pro BNP and fibrinogen and with higher thiols in the whole group of patients reflecting less inflammation and oxidative stress. On the contrary, MFI was negatively associated with antioxidant capacity (thiols/proteins ratio: r = -0.50, p = 0.009) and SaO2 (r = -0.45, p = 0.01) in the high BMI group but also with endothelial function (r = -0.40, p = 0.04) in low BMI COPD.Conclusion: Not only in obese patients but also in lean COPD patients skeletal muscle fat infiltration may contribute to increase cardiometabolic risk factors.