TY - JOUR T1 - Metabolic diseases in parents and grandparents predict asthma and hay fever in offspring JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 482 AU - Anne-Elie Carsin AU - Cecilie Svanes AU - Jordi Sunyer AU - Julia Dratva AU - Dan Norback AU - Mathias Holm AU - Eva Lindberg AU - Bryndís Benediktsdóttir AU - Bertil Forsberg AU - Rain Jõgi AU - Vivi Schlünssen AU - Karl Franklin AU - Thorarinn Gislason AU - Torben Sigsgaard AU - Joachim Heinrich AU - Christer Janson AU - Shyamali Dharmage AU - Ane Johannessen AU - Francisco Gómez Real Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/482.abstract N2 - Background: Metabolic diseases are associated with asthma. While both diseases are heritable, studies on whether family history of metabolic disease predicts asthma and allergy have not been undertaken. We studied whether grand-parents' and parents' cardio-metabolic diseases were associated with asthma and hay fever in the offspring.Methods: Asthma phenotypes were studied across three generations using data from the third stage of the RHINE study (2010-11). The 13,499 participants reported information on their own, offsprings' (n=23,649) and parents'(n=26,854) respiratory health. Parents' and grand-parents' metabolic score were defined by latent variables combining stroke, heart disease, hypertension, diabetes and obesity. Associations between parents' and grand-parents' phenotypes (metabolic scores, asthma), and asthma phenotypes in offspring (asthma <10 years, >10 years, hay fever) were estimated using mixed logistic regression and Structural Equation Modeling.Results: Grandparents' and parents' metabolic score were associated with an increased risk of late-onset asthma (ORgd-mother=1.19, p=.431; ORgd-father=1.75 p=.005; ORparent=1.48 p=.148) and hay fever in offspring (OR=1.30, p=.035; 1.45 p=.001; 0.69 p=.023, respectively), but not with early-onset asthma. Direct effects of grandfather's metabolic score were observed on late asthma and hay fever (β=0.10, p<0.01; β=0.09; p<0.01). Conclusion: This is the first study to show that familial cardio-metabolic disease predicts specific asthma phenotypes and hay fever, independent of familial asthma, suggesting that two distinct pathways carry asthma risk across generations, via familial asthma as well as cardio-metabolic disease. ER -